Author

M. E. Ijsselsteijn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell-cell communication· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Assay:imaging· 2 Assay:proteomics· 2 Research Focus:batch correction / integration· 1

Frequent Co-Authors

N. F. C. C. de Miranda· 3 shared A. Somarakis· 2 shared M. van der Ploeg· 2 shared A. Kirchmair· 1 shared A. Krogsdam· 1 shared A. Mahfouz· 1 shared A. Noureen· 1 shared A. Schaefer· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCancer Biology

N. F. C. C. de Miranda

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Multimodal profiling of chordoma immunity reveals distinct immune contextures

S. van Oost, D. M. Meijer, M. E. Ijsselsteijn, J. P. Roelands, B. E. W. M. van den Akker, R. van der Breggen, I. H. Briaire-de Bruijn, M. van der Ploeg, P. M. Wijers-Koster, S. B. Polak, W. C. Peul, R. J. P. van der Wal, N. F. C. C. de Miranda, J. V. M. G. Bovee

This study profiles chordoma immunity using multimodal approaches, identifying two immune contextures and their association with T cell infiltration and clinical outcomes.

bioRxiv · Sep 14, 2023Cancer Biology

Integration of Mass Cytometry and Mass Spectrometry Imaging for Spatially Resolved Single Cell Metabolic Profiling

J. B. Nunes, M. E. Ijsselsteijn, T. Abdelaal, R. Ursem, M. van der Ploeg, B. Everts, A. Mahfouz, B. Heijs, N. de Miranda

The paper integrates mass cytometry and mass spectrometry imaging to analyze metabolic heterogeneity in tissues and its link to cell populations like cancer and immune cells.

bioRxiv · Aug 29, 2023Cancer Biology

Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer

C. Plattner, G. Lamberti, P. Blattmann, A. Kirchmair, D. Rieder, Z. Loncova, G. Sturm, S. Scheidl, M. E. Ijsselsteijn, G. Fotakis, A. Noureen, R. Lisandrelli, N. Boeck, N. Nemati, A. Krogsdam, , Z. Trajanoski

The paper uses patient-derived organoids and phosphoproteomics to study signaling crosstalk in colorectal cancer and identify off-target effects of kinase inhibitors.

bioRxiv · Sep 16, 2022Cancer Biology

γδ T cells are effectors of immune checkpoint blockade in mismatch repair-deficient colon cancers with antigen presentation defects

N. L. de Vries, J. v. d. Haar, V. Veninga, M. Chalabi, M. E. Ijsselsteijn, M. v. d. Ploeg, J. v. d. Bulk, D. Ruano, J. B. Haanen, T. N. Schumacher, L. F. A. Wessels, F. Koning, N. F. C. C. de Miranda, E. E. Voest

This study shows that γδ T cells, not CD8+ T cells, mediate immune checkpoint blockade efficacy in HLA class I-negative, MMR-d colon cancers.

bioRxiv · Oct 14, 2021 · PreprintCancer Biology

Semi-automated background removal limits loss of data and normalises the images for downstream analysis of imaging mass cytometry data

M. E. Ijsselsteijn, A. Somarakis, B. P. F. Lelieveldt, T. Höllt, N. F. C. C. de Miranda

The paper develops a semi-automated background removal workflow to normalise imaging mass cytometry data, improving data quality and enabling better analysis and comparison of samples.

bioRxiv · Nov 26, 2020Immunology