Author

M. P. Trefny

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1

Frequent Co-Authors

A. Zippelius· 3 shared M. A. Stanczak· 2 shared N. Kirchhammer· 2 shared A. Kashyap· 1 shared A. Kirchmair· 1 shared A. Krogsdam· 1 shared A. M. Sandbichler· 1 shared A. Petrone· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersImmunology

A. Zippelius

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3 papers

Recent·Most cited

13C tracer analysis reveals the landscape of metabolic checkpoints in human CD8+ T cell differentiation

A. Kirchmair, N. Nemati, G. Lamberti, M. P. Trefny, A. Krogsdam, A. Siller, P. Hörtnagl, P. Schumacher, S. Sopper, A. M. Sandbichler, A. Zippelius, B. Ghesquiere, Z. Trajanoski

This study uses 13C metabolomics and transcriptomics to analyze metabolic changes in CD8+ T cells during differentiation, identifying key metabolic checkpoints and their role in exhaustion.

bioRxiv · May 18, 2023 · PreprintImmunology

Adaptive anti-tumor immunity is orchestrated by a population of CCL5-producing tissue-resident NK cells

N. Kirchhammer, M. P. Trefny, M. Natoli, D. Bruecher, S. N. Smith, F. Werner, V. Koch, D. Schreiner, E. Bartoszek, M. Buchi, M. Schmid, D. Breu, K. P. Hartmann, P. Zaytseva, D. S. Thommen, , A. Zippelius

The paper shows that CCL5-producing tissue-resident NK cells are critical for IL-12-mediated anti-tumor immunity and that CCL5 delivery can overcome resistance in tumors with low trNK cell infiltration.

bioRxiv · May 27, 2021 · PreprintImmunology

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade

M. A. Stanczak, N. R. Mantuano, N. Kirchhammer, D. E. Sanin, J. Wang, M. P. Trefny, G. Monaco, M. A. Gray, A. Petrone, A. S. Kashyap, K. Glatz, B. Kasenda, K. Normington, J. Broderick, L. Peng, , H. Laeubli

This study shows that targeting cancer glycosylation with an antibody-sialidase conjugate repolarizes tumor-associated macrophages and enhances immune checkpoint blockade efficacy in mouse models.

bioRxiv · Apr 11, 2021Immunology