J. Engel

The Chlamydia effector IncE employs two short linear motifs to reprogram host vesicle trafficking

This study identifies two short linear motifs in Chlamydia effector IncE that reprogram host vesicle trafficking to support bacterial replication.

Spatial control of sensory adaptation modulates mechanosensing in Pseudomonas aeruginosa

This study identifies a spatial mechanism of sensory adaptation in Pseudomonas aeruginosa, revealing how enzyme localization modulates mechanosensing and virulence.

The Chlamydia trachomatis Inc Tri1 interacts with TRAF7 to displace native TRAF7 interacting partners

This paper identifies the interaction between Chlamydia trachomatis effector Tri1 and host TRAF7, showing Tri1 displaces TRAF7's native binding partners to alter its signaling during infection.

Landscape-scale spatial variations of pre-Columbian anthropogenic disturbances at three ring ditch sites in French Guiana

This study examines spatial variations of pre-Columbian disturbances at three ring ditch sites in French Guiana using soil surveys and multiple indicators, revealing long-term occupation and anthropogenic soil alterations.

Mitotic clustering of pulverized chromosomes from micronuclei

This study shows that acentric chromosome fragments from micronuclei cluster during mitosis, leading to biased inheritance and balanced chromothripsis in cancer.

Chemoenzymatic syntheses of fluorine-18-labeled disaccharides from FDG yield potent sensors of living bacteria in vivo

This paper develops chemoenzymatic methods to synthesize [18F]-labeled disaccharides from FDG, which detect bacteria in vivo by their specific glycan incorporation.

A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening

This paper develops a bead-based immunoassay to quantify GPCR phosphorylation for ligand profiling and GRK inhibitor screening, demonstrating its utility with selective inhibitors.

Chlamydia trachomatis effector Dre1 interacts with dynactin to reposition host organelles during infection

This study identifies Dre1, a Chlamydia effector that interacts with dynactin to reposition host organelles during infection, enhancing bacterial fitness.

Developing Cyclic Peptomers as Broad-Spectrum Gram negative Bacterial Type III Secretion System Inhibitors

This paper identifies a cyclic peptomer, 4EpDN, that broadly inhibits Gram-negative bacterial type III secretion systems without affecting bacterial growth or other secretory systems.