High glucose enhances antigen-independent CTL killing via TRAIL
W. Yang, A. Denger, C. Diener, F. Kueppers, L. Soriano-Baguet, G. Schaefer, A. K. Yanamandra, R. Zhao, A. Knoerck, E. C. Schwarz, M. Hart, F. Lammert, L. P. Roma, D. Brenner, G. Grigorios Christidis, , B. Qu
This study shows high glucose increases TRAIL expression in CTLs, promoting beta cell apoptosis, and identifies metformin and vitamin D as synergistic therapies to mitigate this effect.
bioRxiv · Aug 4, 2021Immunology