E. C. Schwarz

T cell polarization and NFAT translocation are stiffness-dependent and are differentially regulated by Piezo1 and Orai1

This study shows that T cell polarization and NFAT translocation are stiffness-dependent and are regulated by different Ca2+ influx pathways, Piezo1 and Orai1.

High glucose enhances antigen-independent CTL killing via TRAIL

This study shows high glucose increases TRAIL expression in CTLs, promoting beta cell apoptosis, and identifies metformin and vitamin D as synergistic therapies to mitigate this effect.

Collagen density defines 3D migration of CTLs and their consequent cytotoxicity against tumor cells

This study shows that dense collagen matrices impair CTL migration and cytotoxicity, with microtubule networks playing a key role in restoring migration and function.

Cytotoxic efficiency of human CD8+ T cell memory subtypes

This study quantifies the cytotoxic efficiency of human TEM and TCM CD8+ T cell subtypes, finding TEM cells are more effective in inducing apoptosis and necrosis due to higher perforin expression and more efficient lytic synapses.

Identification of molecular candidates which regulate calcium-dependent CD8+ T-cell cytotoxicity

The paper identifies four molecular candidates that regulate Ca2+-dependent CD8+ T-cell cytotoxicity through transcriptome analysis and functional assays.

Interdependence of CTL and NK cells cytotoxicity against melanoma cells

This study examines how CTL and NK cells interact to kill melanoma cells, showing that their cytotoxicity is interdependent and that resistance mechanisms vary based on pre-exposure conditions.

High glucose attenuates Ca2+ influx in cytotoxic T lymphocytes upon target recognition

This study shows high glucose increases store-operated calcium entry but reduces calcium influx during target recognition in CTLs, leading to increased necrosis after killing.