Collagen density defines 3D migration of CTLs and their consequent cytotoxicity against tumor cells
R. Zhao, X. Zhou, E. S. Khan, D. Alansary, K. S. Friedmann, W. Yang, E. C. Schwarz, A. del Campo, M. Hoth, B. Qu
This study shows that dense collagen matrices impair CTL migration and cytotoxicity, with microtubule networks playing a key role in restoring migration and function.
bioRxiv · Mar 16, 2021Immunology