Author

L. P. Roma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

E. Ampofo· 2 shared A. Bautista· 1 shared A. Denger· 1 shared A. Diederich· 1 shared A. F. Spigelman· 1 shared A. K. Yanamandra· 1 shared A. Knoerck· 1 shared A. R. Pepper· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

E. Ampofo

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The NAPstar family of NADP redox state sensors highlights glutathione as the primary mediator of anti-oxidative electron flux

M. Scherschel, J.-O. Niemeier, L. Jacobs, M. Hoffmann, A. Diederich, C. Bell, P. Hoehne, S. Raetz, J. Kroll, J. Steinbeck, S. Lichtenauer, J. Multhoff, J. Zimmermann, T. Sadhanasatish, R. A. Rothemann, , B. Morgan

The paper introduces NAPstar biosensors to measure NADP redox states and finds glutathione mediates anti-oxidative electron flux across eukaryotes.

bioRxiv · Feb 14, 2024 · PreprintBiochemistry

β-cell responses to high fat feeding: A role and mechanism for redox sensing by SENP1

H. Lin, K. Suzuki, N. Smith, X. Li, L. Nalbach, S. Fuentes, A. F. Spigelman, X.-Q. Dai, A. Bautista, M. Ferdaoussi, S. Aggarwal, A. R. Pepper, L. P. Roma, E. Ampofo, W.-h. Li, P. E. MacDonald

This study identifies SENP1's role in β-cell redox sensing during high-fat feeding, showing its requirement for enhanced exocytosis and glucose intolerance.

bioRxiv · Apr 5, 2022Cell Biology

High glucose enhances antigen-independent CTL killing via TRAIL

W. Yang, A. Denger, C. Diener, F. Kueppers, L. Soriano-Baguet, G. Schaefer, A. K. Yanamandra, R. Zhao, A. Knoerck, E. C. Schwarz, M. Hart, F. Lammert, L. P. Roma, D. Brenner, G. Grigorios Christidis, , B. Qu

This study shows high glucose increases TRAIL expression in CTLs, promoting beta cell apoptosis, and identifies metformin and vitamin D as synergistic therapies to mitigate this effect.

bioRxiv · Aug 4, 2021Immunology