Author

A. Konstantoulea

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

F. G. Forster· 2 shared L. Ferrari· 2 shared R. Kos· 2 shared S. G. D. Rudiger· 2 shared W. J. C. Geerts· 2 shared C. Hoogenraad· 1 shared G. van de Kamp· 1 shared L. S. van Bezouwen· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

F. G. Forster

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Author profile →

2 papers

Recent·Most cited

Fibril formation rewires interactome of the Alzheimer protein Tau by π-stacking

L. Ferrari, R. Stucci, A. Konstantoulea, G. van de Kamp, R. Kos, W. J. C. Geerts, F. G. Forster, M. Altelaar, C. Hoogenraad, S. G. D. Rudiger

This study shows that Tau fibrils use π-stacking by arginine side chains to alter protein interactions, attracting specific proteins linked to Alzheimer's and that Hsp90 can suppress these interactions.

bioRxiv · Jan 16, 2019 · PreprintBiochemistry

Human chaperones untangle fibrils of the Alzheimer protein Tau

L. Ferrari, W. J. C. Geerts, M. van Wezel, R. Kos, A. Konstantoulea, L. S. van Bezouwen, F. G. Forster, S. G. D. Rudiger

This study shows human Hsp70 chaperones can dissolve Tau fibrils, while bacterial Hsp70 systems cannot, suggesting evolutionary adaptation for fibril disaggregation and potential therapeutic applications for Alzheimer's.

bioRxiv · Sep 26, 2018 · PreprintBiochemistry