L. Ferrari

A peptide strategy for inhibiting different protein aggregation pathways in disease

The paper develops a peptide strategy that inhibits both amorphous and amyloid protein aggregation by targeting early aggregation stages, showing effectiveness against unrelated proteins like Axin and Tau.

Tackling Recalcitrant Pseudomonas aeruginosa Infections In Critical Illness via Anti-virulence Monotherapy

This study identifies novel anti-MvfR compounds (NAMs) that reduce intestinal permeability and inflammation in Pseudomonas aeruginosa infections, offering a potential monotherapy for critical illness.

A Niclosamide-releasing hot-melt extruded catheter prevents Staphylococcus aureus experimental biomaterial-associated infection

This study develops NIC-releasing catheters to prevent biomaterial-associated infections, showing sustained antibacterial activity against S. aureus in vitro and in vivo.

Recombinant production and purification of the human protein Tau

This paper describes a method to produce and purify human Tau protein recombinantly in E. coli, yielding stable and pure preparations suitable for in vitro studies.

Fibril formation rewires interactome of the Alzheimer protein Tau by π-stacking

This study shows that Tau fibrils use π-stacking by arginine side chains to alter protein interactions, attracting specific proteins linked to Alzheimer's and that Hsp90 can suppress these interactions.

MAP7 family proteins regulate kinesin-1 recruitment and activation

The paper shows that MAP7 family proteins activate kinesin-1 by enhancing its microtubule binding and processivity through transient interactions.

Human chaperones untangle fibrils of the Alzheimer protein Tau

This study shows human Hsp70 chaperones can dissolve Tau fibrils, while bacterial Hsp70 systems cannot, suggesting evolutionary adaptation for fibril disaggregation and potential therapeutic applications for Alzheimer's.