Fibril formation rewires interactome of the Alzheimer protein Tau by π-stacking
L. Ferrari, R. Stucci, A. Konstantoulea, G. van de Kamp, R. Kos, W. J. C. Geerts, F. G. Forster, M. Altelaar, C. Hoogenraad, S. G. D. Rudiger
This study shows that Tau fibrils use π-stacking by arginine side chains to alter protein interactions, attracting specific proteins linked to Alzheimer's and that Hsp90 can suppress these interactions.
bioRxiv · Jan 16, 2019 · PreprintBiochemistry