Liquid-liquid Phase Separation of Alpha-synuclein Increases the Structural Variability of Fibrils Formed during Amyloid Aggregation
M. Ziaunys, D. Sulskis, D. Veiveris, A. Kopustas, R. Snieckute, K. Mikalauskaite, A. Sakalauskas, M. Tutkus, V. Smirnovas
This study compares alpha-synuclein aggregation under conditions that promote or negate liquid-liquid phase separation, showing that phase separation leads to more structurally variable and toxic fibrils.
bioRxiv · Dec 28, 2023Biophysics