Author

M. Zaremba

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Assay:DNA methylation· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

A. Silanskas· 3 shared A. Kopustas· 2 shared A. Leavitt· 2 shared D. Rutkauskas· 2 shared E. Manakova· 2 shared G. Amitai· 2 shared G. Sasnauskas· 2 shared J. Paksaite· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

A. Silanskas

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

TIR domains produce histidine-ADPR conjugates as immune signaling molecules in bacteria

D. Sabonis, C. Avraham, A. Lu, E. Herbst, A. Silanskas, A. Leavitt, E. Yirmiya, M. Zaremba, G. Amitai, P. J. Kranzusch, R. Sorek, G. Tamulaitiene

The paper identifies His-ADPR as a novel TIR-derived immune signaling molecule in bacteria, showing its role in phage defense and structural basis for recognition.

bioRxiv · Jan 3, 2024 · PreprintMicrobiology

Advancing Understanding of DNA-BfiI Restriction Endonuclease Cis and Trans Interactions through smFRET Technology

M. Tutkus, S. Ivanovaite, J. Paksaite, A. Kopustas, G. Karzaite, D. Rutkauskas, A. Silanskas, G. Sasnauskas, M. Zaremba, S. K. Jones

This paper develops smFRET assays to study BfiI-DNA interactions, showing longer binding durations on target sites and minimal conformational changes.

bioRxiv · Mar 31, 2023 · PreprintBiophysics

Multiple phage resistance systems inhibit infection via SIR2-dependent NAD+ depletion

J. Garb, A. Lopatina, A. Bernheim, M. Zaremba, V. Siksnys, S. Melamed, A. Leavitt, A. Millman, G. Amitai, R. Sorek

The paper shows DSR proteins deplete NAD+ during phage infection, inhibiting propagation, and identifies SIR2 domains as effector NADases in bacterial immunity.

bioRxiv · Dec 14, 2021Microbiology

Oriented Soft DNA Curtains for Single Molecule Imaging

A. Kopustas, S. Ivanovaite, T. Rakickas, E. Poceviciute, J. Paksaite, T. Karvelis, M. Zaremba, E. Manakova, M. Tutkus

This paper introduces a new method for creating oriented DNA curtains using protein templates to study protein-DNA interactions with improved stability and controllability.

bioRxiv · Jun 15, 2020Biophysics

Prokaryotic Argonaute from Archaeoglobus fulgidus interacts with DNA as a homodimer

E. Golovinas, D. Rutkauskas, E. Manakova, M. Jankunec, A. Silanskas, G. Sasnauskas, M. Zaremba

This study shows that AfAgo, a prokaryotic Argonaute from Archaeoglobus fulgidus, forms a stable homodimer that interacts with two DNA molecules.

bioRxiv · May 6, 2020Biochemistry