Tumor-specific CD4 T cells instruct monocyte differentiation in pancreatic ductal adenocarcinoma
M. T. Patterson, A. L. Burrack, Y. Xu, Z. C. Schmiechen, P. R. Schrank, A. E. Kennedy, M. M. Firulyova, E. A. Miller, E. Cruz-Hinojoza, K. Zaitsev, J. W. Williams, I. M. Stromnes
This study identifies tumor-specific CD4 T cells as regulators of monocyte differentiation into antitumor macrophages in pancreatic ductal adenocarcinoma, showing their role in suppressing tumor growth.
bioRxiv · Nov 9, 2022 · PreprintImmunology