Author

J. W. Williams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Physiology· 2 Biochemistry· 1 Cancer Biology· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Research Focus:differential expression· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2

Frequent Co-Authors

M. T. Patterson· 5 shared A. E. Kennedy· 3 shared P. R. Schrank· 3 shared Y. Xu· 3 shared A. Zhu· 2 shared G. Fredrickson· 2 shared I. M. Stromnes· 2 shared K. Zaitsev· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersImmunology

M. T. Patterson

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability

M. T. Patterson, Y. Xu, H. Hillman, V. Osinski, P. R. Schrank, A. E. Kennedy, A. Zhu, S. Tollison, S. Shekhar, I. Stromnes, I. Tassi, D. Wu, B. Binstadt, J. W. Williams

This study shows that a Trem2 agonist increases plaque macrophage survival and proliferation while improving plaque stability by enhancing collagen deposition and reducing necrotic core size.

bioRxiv · Sep 21, 2023Immunology

Hepatic lipid-associated macrophages mediate the beneficial effects of bariatric surgery against MASH

G. Fredrickson, K. Florczak, F. Barrow, K. Dietsche, H. Wang, P. Parthiban, R. Almutlaq, O. Adeyi, A. Herman, A. Bartolomucci, C. Staley, C. Jahansouz, J. W. Williams, D. Mashek, S. Ikramuddin, X. Revelo

This study shows that bariatric surgery reduces MASH through TREM2-expressing hepatic macrophages, independent of weight loss.

bioRxiv · Jun 11, 2023 · PreprintPhysiology

Ferroptosis Integrates Mitochondrial Derangements and Pathological Inflammation to Promote Pulmonary Hypertension

F. Kazmirczak, N. T. Vogel, S. Prisco, M. T. Patterson, J. Annis, R. T. Moon, L. M. Hartweck, J. B. Mendelson, M. Kim, N. Laixto Mancripe, T. Markowski, L. Higgins, C. Guerrero, B. Kremer, M. Blake, , K. Prins

This study investigates how ferroptosis contributes to pulmonary hypertension by integrating mitochondrial dysfunction and inflammation, showing that inhibiting ferroptosis reduces disease severity.

bioRxiv · Jan 19, 2023 · PreprintBiochemistry

Trem2 Promotes Foamy Macrophage Lipid Uptake and Survival in Atherosclerosis

M. T. Patterson, M. M. Firulyova, Y. Xu, C. Bishop, A. Zhu, P. R. Schrank, C. E. Ronayne, G. Fredrickson, A. E. Kennedy, N. Acharya, X. Revelo, I. M. Stromnes, T. D. Bold, K. Zaitsev, J. W. Williams

This study identifies Trem2 as a regulator of foamy macrophage differentiation and atherosclerotic plaque growth, showing its role in lipid uptake and cell survival.

bioRxiv · Nov 28, 2022Immunology

Tumor-specific CD4 T cells instruct monocyte differentiation in pancreatic ductal adenocarcinoma

M. T. Patterson, A. L. Burrack, Y. Xu, Z. C. Schmiechen, P. R. Schrank, A. E. Kennedy, M. M. Firulyova, E. A. Miller, E. Cruz-Hinojoza, K. Zaitsev, J. W. Williams, I. M. Stromnes

This study identifies tumor-specific CD4 T cells as regulators of monocyte differentiation into antitumor macrophages in pancreatic ductal adenocarcinoma, showing their role in suppressing tumor growth.

bioRxiv · Nov 9, 2022 · PreprintImmunology

Free fatty acid receptor 4 (FFAR4) regulates cardiac oxylipin balance to promote inflammation resolution in a model of heart failure preserved ejection fraction secondary to metabolic syndrome

N. Zhang, K. A. Murphy, B. Harsch, M. Zhang, D. J. Gyberg, B. M. Wagner, J. Mendelson, M. T. Patterson, D. A. Orchard, C. L. Healy, J. W. Williams, G. C. Shearer, T. O'Connell

This study shows that Ffar4 loss worsens cardiac inflammation and remodeling in male HFpEF-MetS mice by altering oxylipin balance.

bioRxiv · Apr 13, 2022 · PreprintPhysiology

Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis

D. Ma, G. A. Hernandez, A. E. Y. T. Lefebvre, H. Alshetaiwi, K. Blake, K. R. Dave, M. Rauf, J. W. Williams, R. T. Davis, K. T. Evans, M. Y. G. Masoud, R. Lee, R. A. Edwards, M. A. Digman, K. Kessenbrock, D. A. Lawson

This paper develops a 3D tumor sphere culture-transplant system to study human breast cancer metastasis using patient-derived xenografts and validates its utility for functional metastasis assays.

bioRxiv · Jun 25, 2020 · PreprintCancer Biology

Statistically-estimated tree biomass, stem density, and basal area for the upper Midwestern United States at the time of Euro-American settlement

C. J. Paciorek, C. V. Cogbill, J. A. Peters, S. J. Goring, J. W. Williams, D. J. Mladenoff, A. Dawson, J. S. McLachlan

The paper estimates tree biomass, stem density, and basal area in the upper Midwestern US at Euro-American settlement using PLS data and statistical smoothing.

bioRxiv · Dec 2, 2019 · PreprintEcology