Trem2 Promotes Foamy Macrophage Lipid Uptake and Survival in Atherosclerosis
M. T. Patterson, M. M. Firulyova, Y. Xu, C. Bishop, A. Zhu, P. R. Schrank, C. E. Ronayne, G. Fredrickson, A. E. Kennedy, N. Acharya, X. Revelo, I. M. Stromnes, T. D. Bold, K. Zaitsev, J. W. Williams
This study identifies Trem2 as a regulator of foamy macrophage differentiation and atherosclerotic plaque growth, showing its role in lipid uptake and cell survival.
bioRxiv · Nov 28, 2022Immunology