Author

M. T. Patterson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

J. W. Williams· 5 shared A. E. Kennedy· 3 shared P. R. Schrank· 3 shared Y. Xu· 3 shared A. Zhu· 2 shared I. M. Stromnes· 2 shared K. Zaitsev· 2 shared M. M. Firulyova· 2 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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5 shared papersImmunology

J. W. Williams

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability

M. T. Patterson, Y. Xu, H. Hillman, V. Osinski, P. R. Schrank, A. E. Kennedy, A. Zhu, S. Tollison, S. Shekhar, I. Stromnes, I. Tassi, D. Wu, B. Binstadt, J. W. Williams

This study shows that a Trem2 agonist increases plaque macrophage survival and proliferation while improving plaque stability by enhancing collagen deposition and reducing necrotic core size.

bioRxiv · Sep 21, 2023Immunology

Ferroptosis Integrates Mitochondrial Derangements and Pathological Inflammation to Promote Pulmonary Hypertension

F. Kazmirczak, N. T. Vogel, S. Prisco, M. T. Patterson, J. Annis, R. T. Moon, L. M. Hartweck, J. B. Mendelson, M. Kim, N. Laixto Mancripe, T. Markowski, L. Higgins, C. Guerrero, B. Kremer, M. Blake, , K. Prins

This study investigates how ferroptosis contributes to pulmonary hypertension by integrating mitochondrial dysfunction and inflammation, showing that inhibiting ferroptosis reduces disease severity.

bioRxiv · Jan 19, 2023 · PreprintBiochemistry

Trem2 Promotes Foamy Macrophage Lipid Uptake and Survival in Atherosclerosis

M. T. Patterson, M. M. Firulyova, Y. Xu, C. Bishop, A. Zhu, P. R. Schrank, C. E. Ronayne, G. Fredrickson, A. E. Kennedy, N. Acharya, X. Revelo, I. M. Stromnes, T. D. Bold, K. Zaitsev, J. W. Williams

This study identifies Trem2 as a regulator of foamy macrophage differentiation and atherosclerotic plaque growth, showing its role in lipid uptake and cell survival.

bioRxiv · Nov 28, 2022Immunology

Tumor-specific CD4 T cells instruct monocyte differentiation in pancreatic ductal adenocarcinoma

M. T. Patterson, A. L. Burrack, Y. Xu, Z. C. Schmiechen, P. R. Schrank, A. E. Kennedy, M. M. Firulyova, E. A. Miller, E. Cruz-Hinojoza, K. Zaitsev, J. W. Williams, I. M. Stromnes

This study identifies tumor-specific CD4 T cells as regulators of monocyte differentiation into antitumor macrophages in pancreatic ductal adenocarcinoma, showing their role in suppressing tumor growth.

bioRxiv · Nov 9, 2022 · PreprintImmunology

Free fatty acid receptor 4 (FFAR4) regulates cardiac oxylipin balance to promote inflammation resolution in a model of heart failure preserved ejection fraction secondary to metabolic syndrome

N. Zhang, K. A. Murphy, B. Harsch, M. Zhang, D. J. Gyberg, B. M. Wagner, J. Mendelson, M. T. Patterson, D. A. Orchard, C. L. Healy, J. W. Williams, G. C. Shearer, T. O'Connell

This study shows that Ffar4 loss worsens cardiac inflammation and remodeling in male HFpEF-MetS mice by altering oxylipin balance.

bioRxiv · Apr 13, 2022 · PreprintPhysiology