Author

A. L. Miller

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell signaling & trafficking· 6 Organism:Xenopus· 6 Research Focus:development & morphogenesis· 3 Assay:imaging· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

R. E. Stephenson· 3 shared A. B. Goryachev· 2 shared J. Landino· 2 shared L. M. van den Goor· 2 shared A. G. Vecchiarelli· 1 shared A. Michaud· 1 shared B. N. Hall· 1 shared C. M. Field· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCell Biology

R. E. Stephenson

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Author profile →

7 papers

Recent·Most cited

Mechanosensitive recruitment of Vinculin maintains junction integrity and barrier function at epithelial tricellular junctions

L. M. van den Goor, J. Iseler, K. Koning, A. L. Miller

This study shows that Vinculin recruitment to tricellular junctions under tension maintains junction integrity and barrier function in Xenopus embryos.

bioRxiv · Sep 8, 2023Cell Biology

Neighbor cells restrain furrowing during epithelial cytokinesis

J. Landino, E. Misterovich, S. Chumki, A. L. Miller

The paper shows that neighbor cells restrain furrowing during epithelial cytokinesis by generating resistive forces through contractility and stiffness.

bioRxiv · Jun 8, 2023 · PreprintCell Biology

Zinc-based Ultrasensitive Microscopic Barrier Assay (ZnUMBA): a live-imaging method for detecting epithelial barrier breaches with spatiotemporal precision

T. Higashi, R. E. Stephenson, C. Schwayer, K. Huljev, C.-P. Heisenberg, H. Chiba, A. L. Miller

The paper introduces ZnUMBA, a live-imaging method to detect local epithelial barrier breaches with high spatiotemporal precision, and demonstrates its application in Xenopus, zebrafish, and MDCK II cells.

bioRxiv · Sep 27, 2022 · PreprintCell Biology

p115RhoGEF activates RhoA to support tight junction maintenance and remodeling

S. A. Chumki, L. M. van den Goor, B. N. Hall, A. L. Miller

This study identifies p115RhoGEF as a key activator of RhoA at tight junction leaks, showing its role in maintaining and remodeling epithelial barriers.

bioRxiv · Jun 8, 2022Cell Biology

Mechanosensitive calcium signaling promotes epithelial tight junction remodeling by activating RhoA

S. Varadarajan, R. E. Stephenson, E. R. Misterovich, J. L. Wu, I. S. Erofeev, A. B. Goryachev, A. L. Miller

The paper shows that mechanosensitive calcium flashes trigger RhoA activation, leading to tight junction remodeling in response to mechanical stress in Xenopus laevis epithelial cells.

bioRxiv · May 18, 2021Cell Biology

Rho and F-actin self-organize within an artificial cell cortex

J. Landino, M. Leda, A. Michaud, Z. Swider, M. Prom, C. M. Field, W. M. Bement, A. G. Vecchiarelli, A. B. Goryachev, A. L. Miller

This study creates an artificial cell cortex using Xenopus egg extract and lipid bilayers to observe self-organizing Rho and F-actin dynamics similar to those in vivo.

bioRxiv · Apr 9, 2021Cell Biology

The Heterotaxy Gene, CCDC11, is Essential for Cytokinesis and Cell-Cell Adhesion Via RhoA Regulation

S. S. Kulkarni, R. E. Stephenson, S. Amalraj, E. Betleja, J. J. Moresco, J. R. Yates, M. R. Mahjoub, A. L. Miller, M. K. Khokha

This study shows CCDC11 is essential for cytokinesis and cell-cell adhesion via RhoA regulation, linking it to heterotaxy disease pathogenesis.

bioRxiv · Nov 11, 2018 · PreprintCell Biology