A. B. Goryachev

Testing models of cell cortex wave generation by Rho GTPases

This study tests two theoretical models of Rho GTPase wave generation by simultaneously imaging total and active RhoA in cortical waves.

A versatile pattern-forming cortical circuit based on Rho, F-actin, Ect2 and RGA-3/4

The paper identifies Ect2 and RGA-3/4 as core components of a cortical excitability circuit and demonstrates the immature Xenopus oocyte as a model for studying excitable dynamics.

Cell cycle and developmental control of cortical excitability in Xenopus laevis

This study quantifies the onset and changes in cortical excitability in Xenopus laevis eggs and embryos, linking wave properties to cell cycle progression and cell size.

Mechanosensitive calcium signaling promotes epithelial tight junction remodeling by activating RhoA

The paper shows that mechanosensitive calcium flashes trigger RhoA activation, leading to tight junction remodeling in response to mechanical stress in Xenopus laevis epithelial cells.

Rho and F-actin self-organize within an artificial cell cortex

This study creates an artificial cell cortex using Xenopus egg extract and lipid bilayers to observe self-organizing Rho and F-actin dynamics similar to those in vivo.

Cortical myosin minifilaments orchestrate the arrangement of microridge protrusions on epithelial cell surfaces

The paper investigates how cortical myosin II minifilaments drive microridge fission and fusion in zebrafish larvae, leading to ordered arrangement of these protrusions.

Cortical contraction drives the 3D patterning of epithelial cell surfaces

The paper shows how cortical contractions drive the formation of microridges on zebrafish skin cells by reducing membrane tension and promoting precursor fusion.

Autoamplification and competition drive symmetry breaking: Initiation of centriole duplication by the PLK4-STIL network

The paper proposes a biophysical model explaining how the PLK4-STIL network initiates centriole duplication through autoamplification and competition, leading to symmetry breaking.

Local and global Cdc42 GEFs for fission yeast cell polarity are coordinated by microtubules and the Tea1/Tea4/Pom1 axis

This study shows that microtubules and the Tea1/Tea4/Pom1 axis coordinate local and global Cdc42 GEFs in fission yeast to maintain polarized growth.