OTUB1 is a key regulator of RIG-I dependent immune signalling and is targeted for proteasomal degradation by influenza A NS1
A. S. Jahan, E. Biquand, R. Munoz-Moreno, A. Le Quang, C. K.-P. Mok, H. H. Wong, Q. W. Teo, S. Doak, A. Chin, L. L. M. Poon, A. te Velthuis, A. Garcia-Sastre, C. Demeret, S. Sanyal
This study identifies OTUB1 as a regulator of RIG-I immune signaling, showing it is degraded by influenza NS1 to suppress antiviral responses.
bioRxiv · May 15, 2019Biochemistry