Author

Q. W. Teo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Biochemistry· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Assay:proteomics· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

N. C. Wu· 5 shared H. Lv· 4 shared T. J. C. Tan· 3 shared Y. Wang· 3 shared C. S. Graham· 2 shared I. A. Wilson· 2 shared I. R. Shen· 2 shared R. Lei· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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5 shared papersImmunology

N. C. Wu

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies

Y. Wang, H. Lv, R. Lei, Y.-H. Yeung, I. R. Shen, D. Choi, Q. W. Teo, T. J. C. Tan, A. B. Gopal, X. Chen, C. S. Graham, N. C. Wu

This study curates a dataset of influenza HA antibodies and develops an explainable language model to predict antibody specificity, identifying and validating HA stem antibodies.

bioRxiv · Sep 11, 2023 · PreprintImmunology

Widespread impact of immunoglobulin V gene allelic polymorphisms on antibody reactivity

M. Yuan, Z. Feng, H. Lv, N. So, I. R. Shen, T. J. C. Tan, Q. W. Teo, W. O. Ouyang, L. Talmage, I. A. Wilson, N. C. Wu

This study shows that IGV allelic polymorphisms widely affect antibody reactivity by analyzing antibody-antigen structures and experimental data.

bioRxiv · Jun 6, 2023Immunology

Age-related seroprevalence trajectories of seasonal coronaviruses in children

Y. Luo, H. Lv, S. Zhao, Y. Sun, C. Liu, C. Chen, W. Liang, K.-o. Kwok, Q. W. Teo, R. T. So, Y. Lin, Y. Deng, B. Li, Z. Dai, J. Zhu, , X. Mu

This study examines age-related seroprevalence of four seasonal coronaviruses in children and postpartum women, showing waning passive immunity and resurgence of IgGs with age.

bioRxiv · Jul 26, 2022 · PreprintImmunology

Prevalence and mechanisms of evolutionary contingency in human influenza H3N2 neuraminidase

R. Lei, T. J. C. Tan, A. H. Garcia, Y. Wang, C. Teo, G. Gopan, Z. Tavakoli Dargani, Q. W. Teo, C. S. Graham, S. K. Nair, N. C. Wu

The paper identifies deleterious mutations in human influenza H3N2 neuraminidase and reveals epistatic networks shaping its evolution.

bioRxiv · Feb 24, 2022Microbiology

Ring Finger Protein 213 Assembles into a Sensor for ISGylated Proteins with Antimicrobial Activity

F. Thery, L. Martina, C. Asselman, H. Repo, Y. Zhang, K. Sedeyn, G. D. Moschonas, C. Bredow, Q. W. Teo, J. Zhang, M. Vessely, K. Leandro, D. Eggermont, D. De Sutter, K. Boucher, , F. Impens

This study identifies RNF213 as an ISG15-interacting sensor that detects ISGylated proteins and exhibits broad antimicrobial activity against multiple pathogens.

bioRxiv · Jun 3, 2021Cell Biology

Homologous and heterologous serological response to the N-terminal domain of SARS-CoV-2

H. Lv, O. T.-Y. Tsang, R. T. Y. So, Y. Wang, H. Liu, G. K. Yip, Q. W. Teo, Y. Lin, W. Liang, J. Wang, W. W. Ng, I. A. Wilson, M. Peiris, N. C. Wu, C. K. P. Mok

The paper examines the serological response to the N-terminal domain (NTD) of SARS-CoV-2, showing it is less cross-reactive with SARS-CoV and less effective as an immunogen compared to the RBD.

bioRxiv · Feb 17, 2021 · PreprintImmunology

OTUB1 is a key regulator of RIG-I dependent immune signalling and is targeted for proteasomal degradation by influenza A NS1

A. S. Jahan, E. Biquand, R. Munoz-Moreno, A. Le Quang, C. K.-P. Mok, H. H. Wong, Q. W. Teo, S. Doak, A. Chin, L. L. M. Poon, A. te Velthuis, A. Garcia-Sastre, C. Demeret, S. Sanyal

This study identifies OTUB1 as a regulator of RIG-I immune signaling, showing it is degraded by influenza NS1 to suppress antiviral responses.

bioRxiv · May 15, 2019Biochemistry