The paper analyzes deletion-containing viral genomes (DelVGs) in influenza A virus infection, revealing packaging inefficiencies and deletion hotspots.

bioRxiv · May 13, 2021Microbiology

OTUB1 is a key regulator of RIG-I dependent immune signalling and is targeted for proteasomal degradation by influenza A NS1

A. S. Jahan, E. Biquand, R. Munoz-Moreno, A. Le Quang, C. K.-P. Mok, H. H. Wong, Q. W. Teo, S. Doak, A. Chin, L. L. M. Poon, A. te Velthuis, A. Garcia-Sastre, C. Demeret, S. Sanyal

This study identifies OTUB1 as a regulator of RIG-I immune signaling, showing it is degraded by influenza NS1 to suppress antiviral responses.

bioRxiv · May 15, 2019Biochemistry

Mini viral RNAs act as innate immune agonists during influenza virus infection

A. te Velthuis, J. Long, D. L. Bauer, R. Fan, H.-L. Yen, J. Sharps, J. Siegers, M. Killip, H. French, M. J. Oliva-Martin, R. Randall, E. de Wit, D. van Riel, L. Poon, E. Fodor

This study identifies mini viral RNAs (mvRNAs) as activators of the RIG-I sensor, leading to interferon-beta expression and cytokine storm during influenza virus infection.

bioRxiv · Aug 6, 2018Microbiology

Initiation, elongation and realignment during influenza virus mRNA synthesis

A. te Velthuis, J. Oymans

This study investigates the influenza virus RNA polymerase's transcription mechanism, showing that a prime-realign process aids in mRNA synthesis efficiency with specific primer conditions.

bioRxiv · Nov 3, 2017Microbiology

A mechanism for prime-realignment during influenza A virus replication

J. Oymans, A. te Velthuis

This paper investigates the mechanism of prime-realignment during influenza A virus replication, identifying the role of the PB1 subunit's priming loop and helix-loop-helix motif.

bioRxiv · Oct 31, 2017Microbiology