P. Ghorbani

A distinctive tumor compartment in pancreatic lobules defined by nascent stroma and classical tumor cell phenotype

This study identifies a distinctive PDAC niche in pancreatic lobules characterized by nascent stroma and classical tumor cell phenotype, highlighting the role of acinar-to-ductal metaplasia and microenvironmental factors in tumor progression.

Thermoneutral housing does not accelerate metabolic dysfunction-associated fatty liver disease in male or female mice fed a Western diet

This study investigates whether thermoneutral housing accelerates MAFLD in mice fed a Western diet, finding no significant acceleration in disease progression despite sex-specific metabolic effects.

Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection

This study shows that choline metabolism is essential for IL-4-induced macrophage polarization and RELMα expression during helminth infection, affecting immune homeostasis and parasite clearance.

Myeloid deletion and therapeutic activation of AMP-activated protein kinase (AMPK) do not alter atherosclerosis in male or female mice

This study shows that deleting AMPK in myeloid cells or activating it therapeutically does not affect atherosclerosis in male or female mice.

In vitro hepatitis C virus infection and hepatic choline metabolism

This study investigates how hepatitis C virus (HCV) infection affects choline metabolism in liver cells, showing that choline transport and metabolism are modulated during early infection, with varying effects depending on culture conditions.

Characterization of LXR-activating nanoparticle formulations in primary mouse macrophages

This study compares three nanoparticle formulations for delivering an LXR activator to mouse macrophages, finding that redox-sensitive formulations enhance ABCA1 protein expression.

Fatty acid-induced lipotoxicity inhibits choline metabolism independent of ER stress in mouse primary hepatocytes

This study shows that fatty acid-induced lipotoxicity reduces choline uptake and PC synthesis in mouse hepatocytes, independent of ER stress.