W. L. Stanford

Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma

This study identifies pRb as a novel VHL substrate, showing that its hyperstabilization promotes ccRCC tumorigenesis through transcriptional changes.

Differential and lasting gene expression changes in circulating CD8 T cells in chronic HCV infection with cirrhosis and related insights on the role of Hedgehog signaling

This study examines gene expression changes in CD8 T cells from HCV-infected individuals with varying fibrosis stages, identifying lasting hyperfunction and upregulated Hedgehog signaling in cirrhosis.

Identification of a SARS-CoV-2 host metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 and variants of concern Alpha, Delta, and Omicron

This study identifies a MMP2/9-dependent entry pathway for SARS-CoV-2 and variants, showing differential usage and reduced activity in Omicron.

Three-dimensional drug screen identifies HDAC inhibitors as therapeutic agents in mTORC1-driven lymphangioleiomyomatosis

A 3D drug screen identified HDAC inhibitors as effective against mTORC1-driven lymphangioleiomyomatosis by reducing invasion and selectively killing TSC2-/- cells.

Transcriptomically-guided mesendoderm induction of human pluripotent stem cells using a systematically defined culture scheme

This study introduces a method using single-cell seeding and BMP4/Activin A treatment to induce mesendoderm from hPSCs, showing increased mesoderm and endoderm formation.