Steroid Receptor Coactivator-3 is a Key Modulator of Regulatory T Cell-Mediated Tumor Evasion
S. J. Han, P. Jain, Y. Gilad, Y. Xia, N. Sung, M. J. Park, A. M. Dean, R. B. Lanz, J. Xu, C. C. Dacso, D. M. Lonard, B. W. O'Malley
This study shows that deleting SRC-3 in regulatory T cells eradicates tumors in mouse models by enhancing antitumor immunity without autoimmune side effects.
bioRxiv · Mar 28, 2023Cancer Biology