Author

S. J. Han

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2

Frequent Co-Authors

N. Mittal· 3 shared G. Danuser· 2 shared A. Bachir· 1 shared A. Emery· 1 shared A. Groisman· 1 shared A. J. Whitewood· 1 shared A. Leonard· 1 shared A. M. Dean· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersCell Biology

N. Mittal

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Low Shear in Short-Term Impacts Endothelial Cell Traction and Alignment in Long-Term

M. K. Chandurkar, N. Mittal, S. P. Royer-Weeden, S. D. Lehmann, Y. Rho, S. J. Han

This study examines how brief exposure to low shear stress affects endothelial cell traction and alignment over time, revealing lasting changes in cellular behavior.

bioRxiv · Sep 20, 2023Cell Biology

Steroid Receptor Coactivator-3 is a Key Modulator of Regulatory T Cell-Mediated Tumor Evasion

S. J. Han, P. Jain, Y. Gilad, Y. Xia, N. Sung, M. J. Park, A. M. Dean, R. B. Lanz, J. Xu, C. C. Dacso, D. M. Lonard, B. W. O'Malley

This study shows that deleting SRC-3 in regulatory T cells eradicates tumors in mouse models by enhancing antitumor immunity without autoimmune side effects.

bioRxiv · Mar 28, 2023Cancer Biology

Nascent adhesions differentially regulate lamellipodium velocity and persistence

K. R. Carney, A. M. Khan, S. C. Samson, N. Mittal, S. J. Han, M. C. Mendoza, T. C. Bidone

The paper develops a computational model to study how actin and adhesions regulate cell migration, finding that actin polymerization drives protrusion while adhesion lifetime affects velocity and persistence.

bioRxiv · Nov 15, 2021 · PreprintCell Biology

Black Dots: Microcontact-Printed, Reference-Free Traction Force Microscopy

K. M. Beussman, M. Y. Mollica, A. Leonard, J. Miles, J. Hocter, Z. Song, M. Stolla, S. J. Han, A. Emery, W. E. Thomas, N. J. Sniadecki

This paper introduces a traction force microscopy technique called 'black dots' to measure cellular forces without constraining cell shape, finding that higher force correlates with increased spread area, circularity, and F-actin uniformity in platelets.

bioRxiv · Aug 2, 2021Bioengineering

Talin-vinculin precomplex drives adhesion maturation by accelerated force transmission and vinculin recruitment

S. J. Han, E. V. Azarova, A. J. Whitewood, A. Bachir, E. Guttierrez, A. Groisman, A. R. Horwitz, B. T. Goult, K. Dean, G. Danuser

The paper shows that talin's precomplex with vinculin accelerates adhesion maturation by enhancing vinculin recruitment and force transmission.

bioRxiv · Jan 4, 2021 · PreprintCell Biology

Direct Arp2/3-vinculin binding is essential for cell spreading, but only on compliant substrates and in 3D

T. Isogai, K. M. Dean, P. Roudot, Q. Shao, J. D. Cillay, E. S. Welf, M. K. Driscoll, S. P. Royer, N. Mittal, B.-j. Chang, S. J. Han, R. Fiolka, G. Danuser

The paper investigates the role of actin-binding proteins in cell spreading on 2D and 3D substrates, finding that Arp2/3-vinculin binding is critical for 3D spreading but not 2D.

bioRxiv · Sep 4, 2019 · PreprintCell Biology