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2 papers
Recent·Most cited
G. Kuenze, A. M. Duran, H. Woods, K. R. Brewer, E. F. McDonald, C. G. Vanoye, A. L. George, C. R. Sanders, J. Meiler
This paper develops and validates structural models of human KCNQ1 potassium channels to understand mutation-induced dysfunction and guide drug design.
bioRxiv · May 24, 2019Biophysics
H. Huang, G. Kuenze, J. Smith, K. C. Taylor, A. M. Duran, A. Hadziselimovic, J. Meiler, C. Vanoye, A. George, C. Sanders
This study identifies that most KCNQ1 mutations causing long QT syndrome destabilize the voltage sensor domain, leading to mistrafficking and proteasomal degradation.
bioRxiv · Dec 10, 2017Biochemistry