A. George

Androgen receptor signaling blockade enhances NK cell-mediated killing of prostate cancer cells and sensitivity to NK cell checkpoint blockade

This study shows that androgen receptor inhibitors enhance NK cell-mediated killing of prostate cancer cells and sensitivity to NKG2A checkpoint blockade by upregulating HLA-E expression.

From average transient transporter currents to microscopic mechanism -- A Bayesian analysis

This paper uses Bayesian analysis to evaluate the ability of SSME data to identify kinetic parameters and mechanisms of secondary active transporters.

Preclinical Synergistic Combination Therapy of Lurbinectedin with Irinotecan and 5-Fluorouracil in Pancreatic Cancer

This study shows that combining lurbinectedin with irinotecan and 5-FU significantly enhances the killing of pancreatic cancer cells.

TRAIL agonists rescue mice from radiation-induced lung injury

TRAIL agonists reduce radiation-induced lung injury and lethality in mice by inhibiting CCl22 and improving pneumonitis, alveolar-wall thickness, and oxygen desaturation.

Human endometrial KISS1R inhibits stromal cell decidualization in a manner associated with a reduction in ESR1 levels

This study shows KISS1R inhibits human endometrial stromal cell decidualization by reducing ESR1 levels, which affects embryo invasion and pregnancy success.

Quantifying cooperative multisite binding in the hub protein LC8 through Bayesian inference

This paper quantifies cooperative multisite binding in the protein LC8 using Bayesian inference, finding positive cooperativity in LC8-client peptide interactions but not in NudE-dynein intermediate chain interactions.

Restoration and resilience to sea level rise of a salt marsh affected by dieback events in Charleston, SC

This study shows that salt marshes in Charleston, SC, have not fully recovered 10 years after dieback events, highlighting the need for restoration and climate change mitigation.

CyTOF-Lec: Single-cell glycomics analysis reveals glycan features defining cells differentially susceptible to HIV

This study develops CyTOF-Lec to analyze glycan features in human immune cells, revealing that sialic acid levels distinguish HIV-susceptible memory CD4+ T cells.

Visualizing the cytosolic delivery of bioconjugated QDs into T cell lymphocytes

This study visualizes the cytosolic delivery of bioconjugated quantum dots into T cells, showing that monomeric DSS-QDs escape endosomes and exhibit higher mobility than aggregated control QDs.

SARS-CoV-2-specific T cells exhibit unique features reflecting robust helper function, lack of terminal differentiation, and high proliferative potential

The paper characterizes SARS-CoV-2-specific T cells in recovered patients, finding they exhibit robust helper function, reduced terminal differentiation, and high proliferative potential.

BoneMA - Synthesis and Characterization of a Methacrylated Bone-derived Hydrogel for Bioprinting of Vascularized Tissues

This study synthesizes and characterizes a methacrylated bone-derived hydrogel (BoneMA) for bioprinting vascularized tissues, showing its cytocompatibility and ability to form vascular networks.

A systems-biology approach to molecular machines: Exploration of alternative transporter mechanisms

This paper introduces a computational method to explore alternative mechanisms of molecular machines, finding diverse reaction pathways for cotransport with proofreading capabilities.

Eps8 is a convergence point integrating EGFR and integrin trafficking and crosstalk

This study identifies Eps8 as a key integrator of EGFR and integrin trafficking, showing it regulates their endocytosis and adhesion complex dynamics.

Cell-intrinsic genetic regulation of peripheral memory-phenotype T cell frequencies

The paper shows memory T cell frequencies are genetically regulated and stable over time, while recently activated cells are influenced by environmental factors.

Mechanisms of KCNQ1 Channel Dysfunction in Long QT Syndrome Involving Voltage Sensor Domain Mutations

This study identifies that most KCNQ1 mutations causing long QT syndrome destabilize the voltage sensor domain, leading to mistrafficking and proteasomal degradation.