Re-coding of G protein-coupled receptor signaling enables emergent cellular behavior.
F. Dehkhoda, M. Ringuet, E. A. Whitfield, K. Mutunduwe, C. J. Nowell, D. Misganaw, Z. Xu, A. M. Hossain, L. J. Fothergill, S. J. McDougall, J. B. Furness, S. G. B. Furness
The paper shows that co-expression of G protein-coupled receptors can lead to emergent cellular behavior through a switch in downstream signaling, specifically demonstrating a reversal of dopamine D2 receptor activity.
bioRxiv · Dec 18, 2023 · PreprintCell Biology