Author

J. B. Furness

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

B. Callaghan· 2 shared L. J. Fothergill· 2 shared A. Koo· 1 shared A. M. Hossain· 1 shared B. Y. Liu· 1 shared C. C. Au· 1 shared C. Gerard· 1 shared C. J. Nowell· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

B. Callaghan

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Author profile →

4 papers

Recent·Most cited

Re-coding of G protein-coupled receptor signaling enables emergent cellular behavior.

F. Dehkhoda, M. Ringuet, E. A. Whitfield, K. Mutunduwe, C. J. Nowell, D. Misganaw, Z. Xu, A. M. Hossain, L. J. Fothergill, S. J. McDougall, J. B. Furness, S. G. B. Furness

The paper shows that co-expression of G protein-coupled receptors can lead to emergent cellular behavior through a switch in downstream signaling, specifically demonstrating a reversal of dopamine D2 receptor activity.

bioRxiv · Dec 18, 2023 · PreprintCell Biology

Stratification of enterochromaffin cells by single-cell expression analysis

Y. Song, L. J. Fothergill, K. S. Lee, B. Y. Liu, A. Koo, M. Perelis, S. Diwakarla, B. Callaghan, J. Huang, J. Wykosky, J. B. Furness, G. W. Yeo

This study identifies fourteen enterochromaffin cell clusters in the gut using single-cell transcriptomics and spatial analysis, revealing subtypes with distinct functional properties and a Piezo2+ population involved in colon motility.

bioRxiv · Aug 24, 2023Cell Biology

Surface-based Characterization of Gastric Anatomy and Motility using Magnetic Resonance Imaging and Neural Ordinary Differential Equation

X. Wang, J. Cao, K. Han, M. Choi, Y. She, U. Scheven, R. Avci, P. Du, L. K. Cheng, M. R. D. Natale, J. B. Furness, Z. Liu

This paper introduces a method using MRI and neural ODEs to model gastric motility and anatomy in rats, revealing functional regions and muscle activity patterns.

bioRxiv · Oct 17, 2022 · PreprintPhysiology

Unacylated ghrelin and AZP531 suppress the 3D growth of breast cancers

C. C. Au, J. B. Furness, K. Britt, S. Oshchepkova, H. Ladumor, K. Y. Soo, B. Callaghan, C. Gerard, G. Inghirami, V. Mittal, Y. Wang, X.-Y. Huang, J. A. Spector, E. Andreopoulou, P. Zumbo, , K. A. Brown

This study shows unacylated ghrelin and its analog AZP531 inhibit breast cancer growth in 3D cultures and xenografts by suppressing MAPK signaling and inducing apoptosis.

bioRxiv · Jan 22, 2020 · PreprintCancer Biology