Author

C. J. Nowell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. E. Clark· 2 shared B. A. Croker· 2 shared E. M. Kwong· 2 shared R. N. McVicar· 2 shared S. L. Leibel· 2 shared A. Alvarado· 1 shared A. Denardo· 1 shared A. F. Carlin· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

A. E. Clark

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

TRPV4 is expressed by enteric glia and muscularis macrophages of the colon but does not play a prominent role in colonic motility

P. Rajasekhar, S. E. Carbone, S. T. Johnston, C. J. Nowell, L. Wiklendt, E. J. Crampin, Y. She, J. J. DiCello, A. Saito, L. Sorensen, T. Nguyen, K. M. Lee, J. A. Hamilton, S. K. King, E. M. Eriksson, , D. P. Poole

This paper identifies TRPV4-expressing cell types in the colon and shows limited involvement of TRPV4 in colonic motility.

bioRxiv · Jan 9, 2024 · PreprintPhysiology

Re-coding of G protein-coupled receptor signaling enables emergent cellular behavior.

F. Dehkhoda, M. Ringuet, E. A. Whitfield, K. Mutunduwe, C. J. Nowell, D. Misganaw, Z. Xu, A. M. Hossain, L. J. Fothergill, S. J. McDougall, J. B. Furness, S. G. B. Furness

The paper shows that co-expression of G protein-coupled receptors can lead to emergent cellular behavior through a switch in downstream signaling, specifically demonstrating a reversal of dopamine D2 receptor activity.

bioRxiv · Dec 18, 2023 · PreprintCell Biology

The lung employs an intrinsic surfactant-mediated inflammatory response for viral defense

S. L. Leibel, R. N. McVicar, R. Murad, E. M. Kwong, A. E. Clark, A. Alvarado, B. A. Grimmig, R. Nuryyev, R. E. Young, J. C. Lee, W. Peng, Y. P. Zhu, E. Griffis, C. J. Nowell, B. James, , E. Y. Snyder

This study shows that surfactant proteins mediate an intrinsic inflammatory response in the lung to defend against SARS-CoV-2 infection.

bioRxiv · Jan 26, 2023 · PreprintImmunology

Resolving subcellular pH with a quantitative fluorescent lifetime biosensor

J. J. Rennick, C. J. Nowell, C. W. Pouton, A. P. R. Johnston

This paper introduces pHLIM, a method to quantify sub-cellular pH using fluorescent lifetime imaging and deep learning, demonstrating its application in measuring pH changes in cellular compartments.

bioRxiv · Apr 13, 2022Cell Biology

The Prolyl-tRNA Synthetase Inhibitor Halofuginone Inhibits SARS-CoV-2 Infection

D. R. Sandoval, T. Mandel Clausen, C. Nora, J. A. Magida, A. P. Cribbs, A. Denardo, A. E. Clark, A. F. Garretson, J. K. C. Coker, A. Narayanan, S. A. Majowicz, M. Philpott, C. Johansson, J. E. Dunford, C. B. Spliid, , Mazitsch

This study identifies halofuginone as a potent inhibitor of SARS-CoV-2 infection and replication by reducing heparan sulfate biosynthesis and suppressing viral replication.

bioRxiv · Mar 22, 2021 · PreprintMicrobiology