A tRNA-acetylating toxin and detoxifying enzyme in Mycobacterium tuberculosis.
F. G. Tomasi, A. M. J. Hall, J. T. P. Schweber, C. L. Dulberger, K. McGowen, Q. Liu, S. M. Fortune, S. Helaine, E. J. Rubin
The paper identifies a TA system in Mtb, TacAT, where TacT acetylates tRNAs to inhibit translation and Pth reverses this effect, showing Pth's essentiality is unaffected by TacAT's absence.
bioRxiv · Dec 20, 2021Microbiology