S. Matthews

Risk-free polio vaccine: Recombinant expression systems for production of stabilised virus-like particles

This study produces stabilized poliovirus VLPs using recombinant systems, showing equivalent or better immunogenicity than current vaccines.

Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii

This study presents the crystal structure of Toxoplasma gondii GAC and proposes a multi-conformational model for its assembly in the glideosome.

Uncovering the universality of self-replication in protein aggregation and its link to disease.

The paper investigates self-replication in protein aggregates, finding it common in both functional and pathological contexts, with disease-related aggregates replicating faster than biological ones.

Toxoflavin secreted by Pseudomonas alcaliphila inhibits growth of Legionella pneumophila and its host Vermamoeba vermiformis

This study identifies Pseudomonas alcaliphila as a potential inhibitor of Legionella pneumophila growth through toxoflavin production, which also affects its host Vermamoeba vermiformis.

On the genetic architecture of rapidly adapting and convergent life history traits in guppies

This study investigates the genetic architecture of life history traits in guppies, finding polygenic traits underlie rapid adaptation but may limit genetic convergence across populations.

Effect of sublethal prenatal endotoxaemia on murine placental transport systems and lipid homeostasis

This study examines how sublethal prenatal endotoxaemia affects placental transport systems and lipid homeostasis in mice, finding altered transporter expression and lipid levels linked to fetal demise and early labor.

The major subunit of widespread competence pili exhibits a novel and conserved type IV pilin fold

The paper reports the structural and phylogenetic analysis of ComGC, a major pilin subunit of competence pili, revealing a novel and conserved type IV pilin fold across multiple bacterial species.

Thermogenic hydrocarbons fuel a redox stratified subseafloor microbiome in deep sea cold seep sediments

This study profiles microbial activities in deep sea cold seep sediments, revealing hydrocarbon oxidation pathways and their role in sustaining diverse microbial communities across redox gradients.

Global biochemical and structural analysis of the type IV pilus from the Gram-positive bacterium Streptococcus sanguinis

This study presents the first global biochemical and structural analysis of type IV pili in a Gram-positive bacterium, revealing unique features of pilin processing, structure, and function.

A T7 phage factor required for managing RpoS in Escherichia coli

This paper identifies Gp5.7 as a T7 phage protein that inhibits EσS in stationary phase E. coli, enabling T7 development in both exponential and stationary growth phases.