Author

K. McGowen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

E. J. Rubin· 2 shared Q. Liu· 2 shared A. G. Sowalsky· 1 shared A. M. J. Hall· 1 shared A. Mariani· 1 shared A. Muir· 1 shared A. N. Alilin· 1 shared A. T. Ku· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMicrobiology

E. J. Rubin

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cell envelope remodeling requires high concentrations of biotin during Mycobacterium abscessus model lung infection

M. R. Sullivan, K. McGowen, Q. Liu, C. Akusobi, D. C. Young, J. A. Mayfield, S. Raman, I. D. Wolf, D. B. Moody, C. C. Aldrich, A. Muir, E. J. Rubin

This study identifies biotin-dependent fatty acid remodeling as essential for Mycobacterium abscessus survival in the lung, suggesting biotin synthesis and fatty acid metabolism as therapeutic targets.

bioRxiv · Jul 20, 2022 · PreprintMicrobiology

Tumor-derived biomarkers beyond antigen expression enhance efficacy of CD276/B7H3 antibody-drug conjugate in metastatic prostate cancer

S. Agarwal, L. Fang, K. McGowen, J. Yin, J. Bowman, A. N. Alilin, A. T. Ku, E. Corey, M. Roudier, L. True, R. Dumpit, I. Coleman, J. Lee, P. S. Nelson, B. J. Capaldo, , K. Kelly

This study identifies biomarkers beyond B7H3 expression that predict response to a B7H3-ADC in metastatic prostate cancer models, improving therapeutic efficacy.

bioRxiv · Apr 19, 2022 · PreprintCancer Biology

A tRNA-acetylating toxin and detoxifying enzyme in Mycobacterium tuberculosis.

F. G. Tomasi, A. M. J. Hall, J. T. P. Schweber, C. L. Dulberger, K. McGowen, Q. Liu, S. M. Fortune, S. Helaine, E. J. Rubin

The paper identifies a TA system in Mtb, TacAT, where TacT acetylates tRNAs to inhibit translation and Pth reverses this effect, showing Pth's essentiality is unaffected by TacAT's absence.

bioRxiv · Dec 20, 2021Microbiology