A. M. Major

EX VIVO GENE EDITING AND CELL THERAPY FOR HEREDITARY TYROSINEMIA TYPE 1

This study develops an ex vivo CRISPR gene editing protocol for hepatocytes to treat hereditary tyrosinemia type 1, showing successful engraftment and disease correction in mice.

Defective intestinal repair after short-term high fat diet due to loss of efferocytosis

This study shows that short-term high fat diets impair intestinal repair by disrupting efferocytosis, leading to reduced IL-10 production and defective barrier repair.