Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells
H. Jin, N. A. Ladd, A. M. Peev, G. M. Swarbrick, M. Cansler, M. Null, C. T. Boughter, C. McMurtrey, A. Nilsen, K. M. Dobos, W. H. Hildebrand, D. A. Lewinsohn, E. J. Adams, D. M. Lewinsohn, M. Harriff
This study modifies MR1 ligands to assess their impact on MR1-restricted T cell activation, revealing variable IFN-gamma responses and structural dynamics influencing recognition.
bioRxiv · May 11, 2022Immunology