C. T. Boughter

Macrophages tune responses to pathogen dynamics through TLR4 stimulation memory and by licensing susceptibility to IL-10

The paper shows macrophages use TLR4 memory and IL-10 susceptibility gating to adjust inflammation based on pathogen dynamics.

An Integrated Approach to the Characterization of Immune Repertoires Using AIMS: An Automated Immune Molecule Separator

The paper introduces AIMS, a software tool for integrated analysis of immune repertoire data, enabling comparison across TCR, MHC, peptide, antibody, and antigen sequences to identify interaction hotspots.

Conserved Biophysical Compatibility Among the Highly Variable Germline-Encoded Regions Shapes TCR-MHC Interactions

The paper analyzes all possible germline-encoded TCR-MHC contacts in humans, showing that conserved interactions are rare and that biophysical compatibility, not sequence conservation, defines binding orientation.

Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells

This study modifies MR1 ligands to assess their impact on MR1-restricted T cell activation, revealing variable IFN-gamma responses and structural dynamics influencing recognition.

Biochemical Patterns of Antibody Polyreactivity Revealed Through a Bioinformatics-Based Analysis of CDR Loops

The paper identifies biochemical determinants of antibody polyreactivity using a bioinformatics pipeline and develops a classifier with over 75% accuracy.