Author

E. J. Adams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:differential expression· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

C. T. Boughter· 2 shared D. A. Lewinsohn· 2 shared D. M. Lewinsohn· 2 shared G. M. Swarbrick· 2 shared M. Cansler· 2 shared M. Null· 2 shared N. A. Ladd· 2 shared W. H. Hildebrand· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

C. T. Boughter

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Author profile →

5 papers

Recent·Most cited

Ligand-induced segregation from large cell-surface phosphatases is a critical step in γδ TCR triggering

F. Li, S. Roy, J. Niculcea, K. Gould, E. J. Adams, P. A. van der Merwe, K. Choudhuri

This study identifies ligand-induced segregation of phosphatases CD45 and CD148 from {gamma}{delta} TCRs as essential for TCR triggering by nonclassical MHC class Ib antigens.

bioRxiv · Aug 23, 2023Immunology

Delivery of loaded MR1 Monomer Results in Efficient Ligand Exchange to Host MR1 and Subsequent MR1T cell activation

C. A. Kulicke, G. M. Swarbrick, N. A. Ladd, M. Cansler, M. Null, A. Worley, C. Lemon, T. Ahmed, J. Bennett, T. N. Lust, C. M. Heisler, M. E. Huber, J. R. Krawic, L. M. Ankley, S. K. McBride, , M. J. Harriff

The paper demonstrates that delivering MR1 monomers loaded with 5-OP-RU enables ligand exchange to host MR1, leading to MR1T cell activation.

bioRxiv · Jul 11, 2022Immunology

Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells

H. Jin, N. A. Ladd, A. M. Peev, G. M. Swarbrick, M. Cansler, M. Null, C. T. Boughter, C. McMurtrey, A. Nilsen, K. M. Dobos, W. H. Hildebrand, D. A. Lewinsohn, E. J. Adams, D. M. Lewinsohn, M. Harriff

This study modifies MR1 ligands to assess their impact on MR1-restricted T cell activation, revealing variable IFN-gamma responses and structural dynamics influencing recognition.

bioRxiv · May 11, 2022Immunology

Biochemical Patterns of Antibody Polyreactivity Revealed Through a Bioinformatics-Based Analysis of CDR Loops

C. T. Boughter, M. T. Borowska, J. J. Guthmiller, A. Bendelac, P. Wilson, B. Roux, E. J. Adams

The paper identifies biochemical determinants of antibody polyreactivity using a bioinformatics pipeline and develops a classifier with over 75% accuracy.

bioRxiv · Jul 30, 2020Immunology

The Function of the COPII Gene Paralogs SEC23A and SEC23B Are Interchangeable In Vivo

R. Khoriaty, G. Hesketh, A. Bernard, A. C. Weyand, D. Mellacheruvu, G. Zhu, M. J. Hoenerhoff, B. McGee, L. Everett, E. J. Adams, B. Zhang, T. Saunders, A. Nesvizhskii, D. J. Klionsky, J. A. Shavit, , D. Ginsburg

This study shows SEC23A and SEC23B are functionally interchangeable in vivo, suggesting phenotypic differences arise from gene expression rather than protein function.

bioRxiv · Nov 7, 2017Evolutionary Biology