D. M. Lewinsohn

Delivery of loaded MR1 Monomer Results in Efficient Ligand Exchange to Host MR1 and Subsequent MR1T cell activation

The paper demonstrates that delivering MR1 monomers loaded with 5-OP-RU enables ligand exchange to host MR1, leading to MR1T cell activation.

Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells

This study modifies MR1 ligands to assess their impact on MR1-restricted T cell activation, revealing variable IFN-gamma responses and structural dynamics influencing recognition.

MR1-restricted MAIT cells from the human lung mucosal surface have distinct phenotypic, functional, and transcriptomic features that are preserved in HIV infection

This study identifies distinct phenotypic, functional, and transcriptomic features of MR1-restricted MAIT cells in the human lung mucosa, showing their preservation in HIV infection.

Postnatal expansion, maturation and functionality of MR1 T cells in humans

This study examines the postnatal development of MR1-restricted T cells in humans, showing their expansion, maturation, and functional maturation in response to environmental exposure and tuberculosis infection.

Alternative Splicing of MR1 regulates antigen presentation to MAIT cells

This study investigates how alternative splicing of MR1 affects antigen presentation to MAIT cells, finding that only MR1A can activate MAIT cells while MR1B inhibits their activation.