Inhibition of Intracellular Lipolysis Promotes Cancer Cell Adaptation to Hypoxia
X. Zhang, A. M. Saarinen, T. Hitosugi, Z. Wang, L. Wang, T. H. Ho, J. Liu
The paper shows that HIG2 inhibits ATGL to promote lipid droplet accumulation in hypoxic cancer cells, supporting their survival by reducing ROS and apoptosis.
bioRxiv · Aug 28, 2017Biochemistry