Dissecting β-Cardiac Myosin and Cardiac Myosin-Binding Protein C Interactions using a Nanosurf Assay
A. M. Touma, W. Tang, D. V. Rasicci, D. Vang, A. Rai, S. B. Previs, D. M. Warshaw, C. M. Yengo, S. Sivaramakrishnan
This study develops a nanosurf assay to investigate cMyBP-C interactions with actin and myosin, revealing that cMyBP-C inhibits actomyosin motility and that the M-domain and phosphorylation status are critical for this effect.
bioRxiv · Mar 11, 2022 · PreprintBiophysics