Author

D. M. Warshaw

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Microbiology· 2 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 2 Assay:imaging· 2 Approach:biophysical modeling· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

G. E. Ward· 2 shared G. G. Kennedy· 2 shared K. M. Trybus· 2 shared R. V. Stadler· 2 shared S. B. Previs· 2 shared S. R. Nelson· 2 shared S. Walcott· 2 shared A. F. Mead· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMicrobiology

G. E. Ward

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Spatial Relationships Matter: Kinesin-1 Molecular Motors Transport Liposome Cargo Through 3D Microtubule Intersections In Vitro

B. M. Bensel, S. Previs, C. Bookwaler, K. M. Trybus, S. Walcott, D. M. Warshaw

This paper studies how kinesin-1 motors transport liposome cargo through 2D and 3D microtubule intersections, finding that spatial relationships bias directional outcomes, with a higher straight-through rate at 3D intersections.

bioRxiv · Dec 1, 2023 · PreprintBiophysics

The class XIV myosin of Toxoplasma gondii, TgMyoA, is druggable in an animal model of infection

A. Kelsen, R. S. Kent, A. K. Snyder, E. Wehri, S. J. Bishop, R. V. Stadler, C. Powell, B. Martorelli di Genova, P. K. Rompikuntal, M. J. Boulanger, D. M. Warshaw, N. J. Westwood, J. Schaletzky, G. E. Ward

This paper identifies KNX-002 as a specific inhibitor of TgMyoA, reducing parasite motility and disease progression in mice.

bioRxiv · Sep 9, 2022 · PreprintMicrobiology

A circular zone of attachment to the extracellular matrix provides directionality to the motility of Toxoplasma gondii in 3D

R. V. Stadler, S. R. Nelson, D. M. Warshaw, G. E. Ward

This study uses 3D traction force mapping to show that Toxoplasma gondii generates inward-directed forces at a circular zone of attachment to the extracellular matrix, providing directionality to its motility.

bioRxiv · Jun 8, 2022Microbiology

Dissecting β-Cardiac Myosin and Cardiac Myosin-Binding Protein C Interactions using a Nanosurf Assay

A. M. Touma, W. Tang, D. V. Rasicci, D. Vang, A. Rai, S. B. Previs, D. M. Warshaw, C. M. Yengo, S. Sivaramakrishnan

This study develops a nanosurf assay to investigate cMyBP-C interactions with actin and myosin, revealing that cMyBP-C inhibits actomyosin motility and that the M-domain and phosphorylation status are critical for this effect.

bioRxiv · Mar 11, 2022 · PreprintBiophysics

Mechanical characteristics of ultrafast zebrafish larval swimming muscles

A. F. Mead, G. G. Kennedy, B. M. Palmer, A. M. Ebert, D. M. Warshaw

This paper measures mechanical properties of zebrafish larval swimming muscles, finding they generate high power and have extreme contractile speeds.

bioRxiv · Apr 2, 2020Physiology

SKELETAL MyBP-C ISOFORMS TUNE THE MOLECULAR CONTRACTILITY OF DIVERGENT SKELETAL MUSCLE SYSTEMS

A. Li, S. Nelson, S. Rahmanseresht, F. Braet, A. S. Cornachione, S. B. Previs, T. S. O'Leary, J. W. McNamara, D. E. Rassier, S. Sadayappan, M. J. Previs, D. M. Warshaw

This study examines how different MyBP-C isoforms affect contractility in fast- and slow-twitch skeletal muscles using proteomic, biophysical, and modeling approaches.

bioRxiv · Jun 21, 2019Physiology

MYOSIN VA TRANSPORT OF LIPOSOMES IN THREE-DIMENSIONAL ACTIN NETWORKS IS MODULATED BY ACTIN FILAMENT DENSITY, POSITION, AND POLARITY

A. T. Lombardo, S. R. Nelson, G. G. Kennedy, K. M. Trybus, S. Walcott, D. M. Warshaw

This study investigates how actin filament density, position, and polarity affect MyoVa-mediated liposome transport in 3D actin networks using in vitro models and computational simulations.

bioRxiv · Jan 21, 2019Biophysics