A. Rai

Biochemical and structural insights into the auto-inhibited state of Mical1 and its activation by Rab8

This study characterizes the auto-inhibited state of Mical1 and shows how Rab8 binding releases inhibition through structural and biochemical analysis.

Plant species richness and the root economics space drive soil fungal communities

The paper shows that plant species richness and root economics space axes influence soil fungal community composition in a grassland experiment.

Multi-omics discovery of hallmark protein and lipid features of circulating small extracellular vesicles in humans

The paper identifies hallmark protein and lipid features of circulating extracellular vesicles in humans using multi-omics analysis and provides an open-source tool for further exploration.

A Tumour-Specific Molecular Network Promotes Tumour Growth in Drosophila by Enforcing a JNK-YKI Feedforward Loop

This study identifies a tumour-specific molecular network in Drosophila that promotes growth via a JNK-YKI feedforward loop, highlighting its role in cancer hallmarks.

Rho of plant GTPases with geranylgeranylation motif modulate monoterpene indole alkaloid biosynthesis in Catharanthus roseus

This study identifies CrROP3 and CrROP5 as geranylgeranylated ROP GTPases that positively regulate monoterpene indole alkaloid biosynthesis in Catharanthus roseus.

Distinct composition of plasma virome in HIV-infected subjects on antiretroviral therapy compared to controls

This study compares the plasma virome of HIV-infected patients on antiretroviral therapy with controls, finding significant differences in viral composition.

Discovery of 1,3,4-oxadiazoles with slow-action activity against Plasmodium falciparum malaria parasites

The paper identifies new antiplasmodial compounds with slow-action activity but highlights pharmacokinetic limitations for in vivo efficacy.

Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors

This study designs and evaluates nucleotide-based covalent inhibitors for KRasG13C, showing they block nucleotide exchange and oncogenic signaling.

Dissecting β-Cardiac Myosin and Cardiac Myosin-Binding Protein C Interactions using a Nanosurf Assay

This study develops a nanosurf assay to investigate cMyBP-C interactions with actin and myosin, revealing that cMyBP-C inhibits actomyosin motility and that the M-domain and phosphorylation status are critical for this effect.

miRNA mediated downregulation of non-muscle Cyclase associated protein 1 is required for myogenic differentiation

This study shows that miRNA-mediated downregulation of Cap1 is essential for myogenic differentiation by regulating actin dynamics and myoblast fusion.

Photoswitchable epothilone-based microtubule stabilisers allow GFP imaging-compatible, optical control over the microtubule cytoskeleton

This paper introduces photoswitchable epothilone reagents (STEpos) that allow optical control over microtubule stability and dynamics with high spatiotemporal precision.

Lattice defects induced by microtubule-stabilizing agents exert a long-range effect on microtubule growth by promoting catastrophes

This study shows that microtubule-stabilizing agents induce lattice defects that cause long-range catastrophes in microtubule growth.

Two antagonistic microtubule targeting drugs act synergistically to kill cancer cells

The paper identifies Carba1, a microtubule-destabilizing drug, which synergizes with paclitaxel to enhance cancer cell killing in vitro and in vivo.

Pharmaceutical-grade Rigosertib is a Microtubule-destabilizing Agent

This paper shows pharmaceutical-grade rigosertib, with high purity, causes microtubule destabilization in cells, confirming its mechanism of action against cancer cells.

Development of a highly effective African swine fever virus vaccine by deletion of the I177L gene results in sterile immunity against the current epidemic Eurasia strain