Author

A. Manghrani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Assay:long-read sequencing· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

H. M. Al-Hashimi· 2 shared A. Geng· 1 shared A. K. Rangadurai· 1 shared A. Liu· 1 shared B. Liu· 1 shared B. R. Cullen· 1 shared D. Herschlag· 1 shared H. Al-Hashimi· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiophysics

H. M. Al-Hashimi

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3 papers

Recent·Most cited

NMR measurements of transient low-populated tautomeric and anionic Watson-Crick-like G·T/U in RNA:DNA hybrids: Implications for the fidelity of transcription and CRISPR/Cas9 gene editing

O. Szekely, A. K. Rangadurai, S. Gu, A. Manghrani, S. Guseva, H. Al-Hashimi

This study uses NMR to show that G*T/U mismatches in RNA:DNA hybrids can form Watson-Crick-like conformations, potentially contributing to transcription errors and CRISPR/Cas9 off-target effects.

bioRxiv · Aug 24, 2023Biophysics

RNA conformational propensities determine cellular activity

M. L. Kelly, R. Roy, A. Geng, L. R. Ganser, A. Manghrani, B. R. Cullen, U. Schulze-Gahmen, D. Herschlag, H. M. Al-Hashimi

The paper alters and measures conformational propensities of HIV-1 TAR RNA to predict binding affinities and cellular activity.

bioRxiv · Dec 5, 2022 · PreprintBiophysics

Hoogsteen base pairs increase the susceptibility of double-stranded DNA to cytotoxic damage

Y. XU, A. Manghrani, B. Liu, H. Shi, U. Pham, A. Liu, H. M. Al-Hashimi

This study shows that Hoogsteen base pairs in dsDNA increase susceptibility to methylation damage, challenging the assumption that Watson-Crick faces are fully protected.

bioRxiv · May 24, 2020Biochemistry