Author

L. R. Ganser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Assay:structural biology· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

H. M. Al-Hashimi· 4 shared B. R. Cullen· 3 shared M. L. Kelly· 3 shared C.-C. Chu· 2 shared H. P. Bogerd· 2 shared A. D. Kansal· 1 shared A. Geng· 1 shared A. K. Leung· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersBiochemistry

H. M. Al-Hashimi

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Author profile →

5 papers

Recent·Most cited

Switch-like Compaction of Poly(ADP-ribose) Upon Cation Binding

M. Badiee, A. L. Kenet, L. R. Ganser, T. Paul, S. Myong, A. K. Leung

This study shows PAR is stiffer than DNA/RNA and undergoes switch-like compaction in response to cation binding and protein interactions.

bioRxiv · Mar 11, 2023 · PreprintBiophysics

RNA conformational propensities determine cellular activity

M. L. Kelly, R. Roy, A. Geng, L. R. Ganser, A. Manghrani, B. R. Cullen, U. Schulze-Gahmen, D. Herschlag, H. M. Al-Hashimi

The paper alters and measures conformational propensities of HIV-1 TAR RNA to predict binding affinities and cellular activity.

bioRxiv · Dec 5, 2022 · PreprintBiophysics

Revealing the high propensity of RNAs to non-specifically bind drug-like small molecules

M. L. Kelly, C.-C. Chu, H. Shi, L. R. Ganser, H. P. Bogerd, K. Huynh, Y. Hou, B. R. Cullen, H. M. Al-Hashimi

This study examines the non-specific binding of three drug-like compounds to HIV-1 stem-loop RNAs, showing they inhibit RNA function and exhibit off-target interactions.

bioRxiv · May 2, 2020Biochemistry

Probing RNA conformational equilibria within the functional cellular context

L. R. Ganser, C.-C. Chu, H. P. Bogerd, M. L. Kelly, B. R. Cullen, H. M. Al-Hashimi

The paper develops a method to assess RNA excited-state stability and abundance in cells using mutations and applies it to HIV-1 regulatory RNAs, showing ESs form with comparable abundance in vitro and in vivo.

bioRxiv · Sep 1, 2019Biochemistry

High Performance Virtual Screening by Targeting a High-resolution RNA Dynamic Ensemble

L. R. Ganser, J. Lee, B. Sathyamoorthy, A. D. Kansal, D. K. Merriman, H. M. Al-Hashimi

The paper evaluates ensemble-based virtual screening for RNA targets using a high-resolution TAR RNA ensemble and shows improved accuracy over single-structure docking.

bioRxiv · Jun 18, 2017Biochemistry