Author

M. L. Kelly

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:C. elegans· 1 Research Focus:cell-cell communication· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

B. R. Cullen· 3 shared H. M. Al-Hashimi· 3 shared L. R. Ganser· 3 shared C.-C. Chu· 2 shared H. P. Bogerd· 2 shared A. Geng· 1 shared A. Manghrani· 1 shared D. Herschlag· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiochemistry

B. R. Cullen

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Author profile →

4 papers

Recent·Most cited

A tale of two phage tails: Engineering the host range of bacteriophages infecting Clostridioides difficile

J. P. Steczynska, S. J. Kerr, M. L. Kelly, M. J. Whittle, T. W. Bilverstone, N. P. Minton

This paper expands the host range of C. difficile phages by engineering their tail fibre and associated chaperone genes using CRISPR/Cas9, resulting in a phage with broader host range and higher infection efficiency.

bioRxiv · Oct 16, 2023 · PreprintMicrobiology

RNA conformational propensities determine cellular activity

M. L. Kelly, R. Roy, A. Geng, L. R. Ganser, A. Manghrani, B. R. Cullen, U. Schulze-Gahmen, D. Herschlag, H. M. Al-Hashimi

The paper alters and measures conformational propensities of HIV-1 TAR RNA to predict binding affinities and cellular activity.

bioRxiv · Dec 5, 2022 · PreprintBiophysics

Revealing the high propensity of RNAs to non-specifically bind drug-like small molecules

M. L. Kelly, C.-C. Chu, H. Shi, L. R. Ganser, H. P. Bogerd, K. Huynh, Y. Hou, B. R. Cullen, H. M. Al-Hashimi

This study examines the non-specific binding of three drug-like compounds to HIV-1 stem-loop RNAs, showing they inhibit RNA function and exhibit off-target interactions.

bioRxiv · May 2, 2020Biochemistry

Probing RNA conformational equilibria within the functional cellular context

L. R. Ganser, C.-C. Chu, H. P. Bogerd, M. L. Kelly, B. R. Cullen, H. M. Al-Hashimi

The paper develops a method to assess RNA excited-state stability and abundance in cells using mutations and applies it to HIV-1 regulatory RNAs, showing ESs form with comparable abundance in vitro and in vivo.

bioRxiv · Sep 1, 2019Biochemistry