An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function
N. Cuesta, J. M. Contreras, J. Sanchez-Waldermer, P. Soriano-Maldonado, A. Martin-Hurtado, I. M. Munoz, M. Llimargas, J. Munoz, I. Plaza-Menacho
This paper identifies an allosteric switch between c-Src's activation loop and a c-terminal phospho-motif that regulates auto-phosphorylation, enzyme specificity, and non-catalytic function.
bioRxiv · Oct 16, 2022Biochemistry