J. Munoz

Detailed Survey of an in-vitro Intestinal Epithelium Model by Single-Cell Transcriptomics

This study uses single-cell RNA sequencing to analyze a Caco-2/HT29 co-culture model, identifying cell types and assessing its similarity to human intestinal epithelium, finding it lacks some transporters and immune markers.

Latitudinal gradients in predation persist in urban environments

The paper tests if urbanization disrupts latitudinal gradients in seed predation across 14,000 km of latitude, finding that gradients persist despite habitat modification.

An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function

This paper identifies an allosteric switch between c-Src's activation loop and a c-terminal phospho-motif that regulates auto-phosphorylation, enzyme specificity, and non-catalytic function.

Induction of senescence renders cancer cells highly immunogenic

This study shows that inducing senescence in cancer cells enhances their immunogenicity, leading to stronger anti-tumor immune responses compared to immunogenic cell death.

Mast cells impair melanoma cell homing and metastasis by inhibiting HMGA1 secretion.

This study shows mast cells inhibit melanoma metastasis by reducing HMGA1 secretion, with HMGA1 expression linked to poorer survival in human melanoma.

Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation

The paper determines the structure of the RAF1-HSP90-CDC37 complex using cryo-EM, revealing how CDC37 regulates RAF1 and potential therapeutic targets.

Identification of CRF66_BF, a new HIV-1 circulating recombinant form of South American origin

The paper identifies CRF66_BF, a new HIV-1 circulating recombinant form of South American origin, distinct from CRF12_BF and prevalent in Paraguay.

NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and suppresses PDAC initiation

This study identifies NFIC as a regulator of acinar cell differentiation and ER stress, showing its role in suppressing pancreatic ductal adenocarcinoma initiation.

Inactivation of EMILIN-1 by proteolysis and secretion in small extracellular vesicles favors melanoma progression and metastasis.

The paper shows that EMILIN-1 is proteolyzed and secreted in small EVs, reducing its tumor suppressive effects and promoting melanoma progression and metastasis.

Plasmodium falciparum and helminth coinfections increase IgE and parasite-specific IgG responses

This study examines how co-infections with Plasmodium falciparum and helminths affect antibody responses in Mozambican individuals, finding increased IgE and IgG levels in co-infected individuals.

Diversity of an uncommon elastic hypersaline microbial mat along a small-scale transect

The paper assesses microbial diversity and metabolome profiles in a hypersaline microbial mat across a small transect, revealing low taxonomic diversity and distinct metabolomic signatures.

Mobile microscopy and telemedicine platform assisted by deep learning for quantification of Trichuris trichiura infection.

This paper presents a mobile microscopy and telemedicine platform with deep learning for automated quantification of Trichuris trichiura infection, achieving high precision and recall in stool sample analysis.

Oncogenic RAS instructs morphological transformation of human epithelia via differential tissue mechanics.

This study shows that oncogenic RAS causes morphological changes in human epithelial tissues through differential mechanics, leading to three-dimensional structures similar to cancer behaviors.

A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner

This study identifies a cell cycle kinase-phosphatase module that restrains PI3K-Akt activity through mTORC1-dependent phosphorylation of IRS1 and GRB10.

A drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent local relapse and treat established brain metastasis

The paper introduces a drug-screening platform using organotypic cultures to identify effective treatments for brain metastasis, finding a potent HSP90 inhibitor that works against mouse and human metastases.

Wnt-mediated interactions of tumor-initiating cells with a macrophage niche drive skin tumor formation

The paper identifies a macrophage-tumor-initiating cell niche regulated by Wnt signaling that drives skin tumor formation and maintenance.

Antimetastatic dsRNA mimics identified by live imaging of pathogenic neolymphangiogenesis

The paper identifies dsRNA mimics as inhibitors of lymphangiogenesis and metastasis using live imaging models of melanoma.

HIGH PREVALENCE OF STRONGYLOIDIASIS IN SPAIN: A HOSPITAL-BASED STUDY

This study reports a 9.04% seroprevalence of Strongyloides stercoralis in migrant populations in Spain, with higher rates in Africa and Latin America and lower rates in Asian and East European populations.

A novel microRNA-based strategy to expand the differentiation potency of stem cells

This study shows that transient exposure to miR-203 enhances the differentiation capacity of murine and human PSCs by reversing DNA methylation.

Relevance of screening for Chagas and viral hepatitis in Bolivian migrants

The paper assesses the prevalence of T. cruzi, S. stercoralis, HIV, and viral hepatitis in Bolivian migrants in Spain, finding high rates of T. cruzi and S. stercoralis but low rates of HBV, questioning systematic HBV screening in this group.

Exosomes are key regulators of non-cell autonomous communication in senescence

This study identifies exosomes as key mediators of non-cell autonomous senescence by transmitting the senescent phenotype through a non-canonical interferon pathway.

Seed predation increases from the Arctic to the Equator and from high to low elevations

The paper finds that post-dispersal seed predation increases from the Arctic to the Equator and from high to low elevations, driven by climate seasonality rather than productivity or biodiversity.