Author

A. McMellen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

B. G. Bitler· 2 shared H. Kim· 2 shared T. M. Yamamoto· 2 shared Z. L. Watson· 2 shared D. M. Cittelly· 1 shared E. Nurmemmedov· 1 shared H. Wilson· 1 shared J. Aguilera· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

B. G. Bitler

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2 papers

Recent·Most cited

Targeting BRPF3 moderately reverses olaparib resistance in high grade serous ovarian carcinoma

B. G. Bitler, T. M. Yamamoto, A. McMellen, H. Kim, Z. L. Watson

This study investigates the role of H3K14ac and associated proteins in PARPi resistance in HGSOC, finding that BRPF3 knockdown reduces resistance while HBO1 inhibition does not.

bioRxiv · Dec 21, 2021Cancer Biology

Targeting Wnt Signaling To Overcome PARP Inhibitor Resistance

T. M. Yamamoto, A. McMellen, Z. L. Watson, J. Aguilera, M. J. Sikora, R. Ferguson, E. Nurmemmedov, T. Thakar, M. George-Lucian, H. Kim, D. M. Cittelly, H. Wilson, K. Behbakht, B. G. Bitler

This study identifies Wnt signaling activation as a mechanism of PARP inhibitor resistance in HGSOC and shows that combining PARPi with Wnt inhibitors reduces tumor burden.

bioRxiv · Jul 27, 2018 · PreprintCancer Biology