Z. L. Watson

Combination CDC-like kinase inhibition (CLK)/Dual-specificity tyrosine-regulated kinase (DYRK) and taxane therapy in CTNNB1-mutated endometrial cancer

This paper evaluates SM08502, a CLK/DYRK inhibitor, as a single-agent and in combination with paclitaxel for CTNNB1-mutated endometrial cancer, showing synergistic effects and tumor volume reduction in vitro and in vivo.

Combinatory EHMT and PARP inhibition induces an interferon response and a CD8 T cell-dependent tumor regression in PARP inhibitor-resistant models

Rare Ribosomal RNA Sequences from Archaea Stabilize the Bacterial Ribosome

This study identifies sequence variations in archaeal ribosomes that stabilize the ribosome at high temperatures and creates a stable mutant bacterial ribosome for engineering.

Targeting BRPF3 moderately reverses olaparib resistance in high grade serous ovarian carcinoma

This study investigates the role of H3K14ac and associated proteins in PARPi resistance in HGSOC, finding that BRPF3 knockdown reduces resistance while HBO1 inhibition does not.

Structure of the Bacterial Ribosome at 2 A Resolution

This paper presents a 2.0 Å resolution model of the E. coli 70S ribosome using cryo-EM, revealing detailed chemical interactions, modifications, and solvation.

Eliciting OTUD3/RIPK-Dependent Necroptosis to Prevent Epithelial Ovarian Cancer

This study investigates necroptosis as a potential prevention strategy for high-grade serous ovarian cancer by analyzing gene expression and testing treatments that induce necroptosis in HGSOC cells.

Defects in the assembly of ribosomes selected for β-amino acid incorporation

This study investigates a mutant ribosome, P7A7, evolved for β-amino acid incorporation, revealing defects in its assembly that reduce in vitro activity.

Monolayer-crystal streptavidin support films provide an internal standard of cryo-EM image quality

The paper shows that image quality of cryo-EM samples can be predicted by the quality of streptavidin monolayer crystals, enabling better data selection.