B. G. Bitler

αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation

This study shows that αKG-mediated carnitine synthesis supports HR proficiency by promoting histone acetylation, which enhances DNA repair.

The spatial structure of the tumor immune microenvironment can explain and predict patient response in high-grade serous carcinoma

The paper uses spatial data from ovarian cancer tumors to show that spatial organization of the immune microenvironment correlates with patient outcomes and can predict treatment response.

Claudin-4 modulates autophagy via SLC1A5/LAT1 as a tolerance mechanism for genomic instability in ovarian cancer.

This study shows claudin-4 promotes genomic instability tolerance in ovarian cancer by linking cell junctions to autophagy via SLC1A5/LAT1, and targeting it enhances PARPi efficacy.

The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming

This study shows that chemotherapy-induced senescence-associated secretome promotes metastasis in ovarian cancer by reprogramming metabolism and increasing cell detachment.

Combination CDC-like kinase inhibition (CLK)/Dual-specificity tyrosine-regulated kinase (DYRK) and taxane therapy in CTNNB1-mutated endometrial cancer

This paper evaluates SM08502, a CLK/DYRK inhibitor, as a single-agent and in combination with paclitaxel for CTNNB1-mutated endometrial cancer, showing synergistic effects and tumor volume reduction in vitro and in vivo.

Combinatory EHMT and PARP inhibition induces an interferon response and a CD8 T cell-dependent tumor regression in PARP inhibitor-resistant models

WNT4 regulates cellular metabolism via intracellular activity at the mitochondria in breast and gynecologic cancers

This study identifies WNT4's role in regulating cancer metabolism through mitochondrial intracellular signaling in breast and gynecologic cancers, linking genetic variants to metabolic remodeling.

Targeting BRPF3 moderately reverses olaparib resistance in high grade serous ovarian carcinoma

This study investigates the role of H3K14ac and associated proteins in PARPi resistance in HGSOC, finding that BRPF3 knockdown reduces resistance while HBO1 inhibition does not.

The capacity of the ovarian cancer tumor microenvironment to integrate inflammation signaling conveys a shorter disease-free interval

This study identifies an IL-6/IER3 inflammatory signaling axis linked to chemo-resistance in ovarian cancer by analyzing pre- and post-chemotherapy tumor microenvironment changes.

Expression and T cell Regulatory Action of the PD-1 Immune Checkpoint in the Ovary and Fallopian Tube

This study shows PD-1 and its ligands are expressed by ovarian and fallopian tube cells, with functional implications for T cell regulation and immune privilege in reproductive tissues.

Eliciting OTUD3/RIPK-Dependent Necroptosis to Prevent Epithelial Ovarian Cancer

This study investigates necroptosis as a potential prevention strategy for high-grade serous ovarian cancer by analyzing gene expression and testing treatments that induce necroptosis in HGSOC cells.

WNT4 and WNT3A activate cell autonomous Wnt signaling independent of PORCN or secretion

The paper shows WNT4 and WNT3A can activate cell-autonomous Wnt signaling without requiring PORCN or secretion.

Targeting IDH1 as a pro-senescent therapy in high-grade serous ovarian cancer

This study identifies IDH1 as a therapeutic target in HGSC by showing its role in promoting metabolic adaptation and epigenetic repression, leading to senescence when inhibited.